![]() 2 The recombinant coagulation factor Xa protein sequesters their anticoagulation effect. 1Īndexanet alfa (Andexxa, Portola Pharmaceuticals) was approved by the FDA in May for emergency reversal of two direct factor Xa inhibitors, rivaroxaban and apixaban. DOAC bleeding risk occurs at an annual rate of 2.1% to 3.5% and increases during surgical interventions. ![]() They allow for less frequent INR sticks, consistent dosing regimens, and food choice flexibility. Direct oral anticoagulants (DOACs) have revolutionized the drug market.
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